母親の喫煙,代謝遺伝子の多形態化,乳児の出生体重
Xiaobin Wang1, Barry Zuckerman, Colleen Pearson
1Department of Pediatrics, Boston University School of Medicine and Boston Medical Center, 91 E Concord St, Maternity 4, Boston, MA 02118, USA. xbwang@bu.edu
JAMA
|January 12, 2002
まとめ
CYP1A1とGSTT1の母性遺伝的変異は,タバコの煙が乳児の出生体重にどのように影響するかに影響します. 特定のゲノタイプは,胎児の成長に対する喫煙の負の影響を増幅します.
科学分野:
- 遺伝学 遺伝学とは
- 環境衛生 環境衛生 環境衛生
- 産科は産婦人科です.
背景:
- タバコの煙と不良な妊娠の結果に対する遺伝的感受性は,十分に理解されていません.
- 遺伝子と環境の相互作用を調査することは,妊娠の合併症を理解するために非常に重要です.
研究 の 目的:
- CYP1A1とGSTT1の母性遺伝的変異が,喫煙と乳児の出生体重との関連性を変化させるかどうかを調べる.
- 胎児の発達に影響を与える特定の遺伝子環境相互作用を特定する.
主な方法:
- 741人の母親 (174人の喫煙者,567人の非喫煙者) を対象としたケース・コントロール研究.
- 母親の喫煙状況とCYP1A1/GSTT1遺伝子型との関係で,出生体重と妊娠期間を分析した.
- 症例には,早産または低出生体重の乳児が含まれ,対照群は,満期,低出生体重でない乳児でした.
主要な成果:
- 母親の喫煙は,出生時の体重 (377g) の減少と関連していました.
- CYP1A1 (Aa/aa) とGSTT1 (欠席) ゲノタイプは,喫煙者の出生体重減少を1285gまで大幅に増幅しました.
- 非喫煙者において,これらのゲノタイプによる独立した有害な効果は観察されなかった.
結論:
- 母親のCYP1A1およびGSTT1ゲノタイプは,喫煙が乳児の出生体重に与える影響を大幅に変更します.
- これらの発見は,特定の代謝遺伝子と,妊娠中の喫煙のような環境暴露との間の重要な相互作用を示唆しています.
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