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関連する概念動画

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
Microbial Corrosion01:24

Microbial Corrosion

Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...

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関連する実験動画

Updated: Jun 23, 2026

MicroRNA-based Regulation of Picornavirus Tropism
09:05

MicroRNA-based Regulation of Picornavirus Tropism

Published on: February 6, 2017

マイクロRNA:大きな可能性を持つ微小なレギュレータ.

V Ambros1

  • 1Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA. vra@dartmouth.edu

Cell
|January 10, 2002
PubMed
まとめ
この要約は機械生成です。

マイクロRNAとして知られる小さな調節性RNAは,動物のゲノムに豊富に存在する. その多様性と広範な存在は,様々な遺伝的調節経路における重要な役割を示唆しています.

さらに関連する動画

A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools
09:29

A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools

Published on: August 21, 2019

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

関連する実験動画

Last Updated: Jun 23, 2026

MicroRNA-based Regulation of Picornavirus Tropism
09:05

MicroRNA-based Regulation of Picornavirus Tropism

Published on: February 6, 2017

A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools
09:29

A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools

Published on: August 21, 2019

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

科学分野:

  • ゲノミクスゲノミクスとは
  • 分子生物学は分子生物学である.
  • RNA 生物学 RNA 生物学

背景:

  • 動物のゲノムには,多数の小さな遺伝子がコード化されています.
  • これらの遺伝子は,約22ヌクレオチドの長さで,規制RNAを生成する.
  • これらの小さなRNAは,マイクロRNAとして識別されます.

研究 の 目的:

  • マイクロRNAの特性を調査する.
  • 遺伝子調節におけるマイクロRNAの潜在的な役割を理解する.

主な方法:

  • 動物ゲノムのバイオ情報分析.
  • 小型のRNAの配列分析.
  • 進化的分布を評価するための比較ゲノミクス.

主要な成果:

  • マイクロRNAの核酸配列は多様です.
  • マイクロRNAは,異なる組織または状態で多様な発現パターンを表します.
  • マイクロRNAは,進化的に動物種全体に広がっていることが判明しました.

結論:

  • マイクロRNAの配列の多様性と広範な進化的存在は,重要な生物学的機能を示している.
  • マイクロRNAは,遺伝的規制ネットワークの広範な範囲で重要な役割を果たしている可能性が高い.
  • マイクロRNAの機能に関するさらなる研究は,遺伝子発現と細胞プロセスへの影響を明らかにするために正当化されています.