関連する実験動画

Updated: Jun 9, 2026

In vitro Uncoating of HIV-1 Cores
10:49

In vitro Uncoating of HIV-1 Cores

Published on: November 8, 2011

未成熟のHIV-1キャプシドの組み立てに不可欠な宿主タンパク質の特定

Concepcion Zimmerman1, Kevin C Klein, Patti K Kiser

  • 1Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA.

Nature
|January 10, 2002
PubMed
まとめ

人間のタンパク質HP68は,未熟なヒト免疫不全ウイルス1型 (HIV-1) カプシドの適切な組み立てに不可欠です. この宿主因子は,HIV-1の組み立てと感染性における翻訳後のイベントにおいて重要な役割を果たします.

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関連する概念動画

Viral Structure00:56

Viral Structure

Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
Protein Complex Assembly02:41

Protein Complex Assembly

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Leaky Scanning02:28

Leaky Scanning

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Coat Assembly and GTPases01:33

Coat Assembly and GTPases

Vesicles incorporate different coat protein subunits in different cell locations, which changes the properties of the coat, such as the shape and geometry of the transport vesicles. Thus, vesicle coat proteins also play a significant role in cargo selection.
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Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Inhibitors of Virion Maturation and Assembly01:19

Inhibitors of Virion Maturation and Assembly

As part of their replication cycle, certain viruses synthesize long precursor proteins called polyproteins within infected host cells. In human immunodeficiency virus (HIV), two major polyproteins are produced: Gag and Gag-Pol. The Gag polyprotein supplies the structural components of the virus, while Gag-Pol includes essential viral enzymes such as reverse transcriptase, integrase, and protease. After synthesis, these polyproteins move to the host cell membrane, where they assemble into an...