活性化されたモノサイトは,滑らかな筋肉の細胞死を誘発する:マクロファージのコロニー刺激因子と細胞接触の役割

Puvi N Seshiah1, Dean J Kereiakes, Sanjay S Vasudevan

  • 1Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA, USA.

Circulation
|January 16, 2002
PubMed
まとめ

モノサイトとマクロファージコロニー刺激因子 (M-CSF) は,血管滑らかな筋肉細胞 (VSMC) 死亡を誘発する. Mac-1受容体を標的とする薬剤アブキシマブ (abciximab) は,このプロセスを防ぐことができ,心臓血管疾患の治療への潜在的な道を提供します.

関連する概念動画

Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
Normal cells contain receptors that prevent them from being recognized by phagocytes.
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...