ラソノリドA:非自然 (-) -エナンチオメールの構造的修正と合成

Eun Lee1, Ho Young Song, Jung Won Kang

  • 1School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-747, Korea.

まとめ

非自然なラソノリドAの全合成が達成されました. 主要なテトラヒドロピラニル断片は,ラジカルサイクライゼーションを使用してステレオ選択的に準備され,自然製品の構造を確認しました.

関連する概念動画

Naming Enantiomers02:21

Naming Enantiomers

The naming of enantiomers employs the Cahn–Ingold–Prelog rules that involve assigning priorities to different substituent groups at a chiral center. Each enantiomer, being a distinct molecule, is assigned a unique name by the Cahn–Ingold–Prelog (CIP) rules, also called the R–S system. The prefix R- or S- attached to the chiral centers in an enantiomer is dependent on the spatial arrangement of the four substituents on the chiral center. The R–S system essentially comprises three steps:...
Prochirality02:05

Prochirality

The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...