中性エンドペプチダゼは,ヒトの大動脈弁の狭窄症および心不全における心筋細胞で活性化されます
Jens Fielitz1, Andreas Dendorfer, Reinhard Pregla
1Klinik für Herz-, Gefäss- und Thoraxchirurgie, DHZB (R.P., H.R.Z., R.H., V.R.-Z.), Berlin, Germany.
Circulation
|January 24, 2002
まとめ
心中中性エンドペプチダゼ (NEP) は,ヒトの心不全および大動脈狭窄症で上昇しています. この増加したNEP活動は,心臓におけるブラジキニンとナトリウレチンペプチドを退化させる可能性があります.
科学分野:
- 心血管生物学 心血管生物学
- 酵素学 酵素学とは
- 分子心臓病学 分子心臓病学
背景:
- 心中中性エンドペプチダゼ (NEP) は,心臓内のペプチドを調節する役割を果たします.
- 人間の心筋縮と心不全におけるNEPの調節を調査した.
研究 の 目的:
- 人間の心筋縮および心不全における心中中性エンドペプチダース (NEP) の調節を調査する.
主な方法:
- 左心室生検におけるリアルタイムPCRを用いた定量化されたNEP mRNA.
- 測定された心筋筋NEP酵素活性.
- 免疫光顕微鏡とインシットPCRによる局所的なNEP発現.
主要な成果:
- NEP mRNAレベルは,対照群と比較して,大動脈弁の狭窄症 (AS) と拡張性心筋病 (DCM) の患者に有意に増加しました.
- NEP mRNAの増加は,ASおよびDCMにおける終末ダイアストリック圧の上昇と相関する.
- 心筋NEPの酵素活性もASとDCMの患者で著しく上昇した.
- NEPは,心筋内にあるミオサイトと非ミオサイトの両方の細胞に局在していた.
結論:
- 圧力に負荷を負い,衰弱する人間の心臓において,心臓のNEP活動が高まっていることが実証されています.
- この増加は,ブラジキニンとナトリウレチンペプチドの局所的な分解の強化につながる可能性があります.
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