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Updated: Jul 7, 2026

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
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Published on: August 1, 2018

遺伝子発現プロファイリングによる高リスク乳がん患者の特定

André Ahr, Thomas Karn, Christine Solbach

    Lancet (London, England)
    |January 26, 2002
    PubMed
    まとめ

    分子プロファイリングにより,転移に弱い高リスク乳がんサブタイプ (Aクラス) が特定されました. このグループのノード・ネガティブな患者でさえ,病気の進行が遠隔で示され,個別化された治療法の必要性を示した.

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    Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...