双極性障害の双極性障害とは
Bruno Müller-Oerlinghausen1, Anne Berghöfer, Michael Bauer
1Department of Psychiatry, Research Group of Clinical Psychopharmacology, Freie Universität Berlin, Berlin, Germany.bmoe@zedat.fu-berlin.de
Lancet (London, England)
|January 29, 2002
まとめ
深刻な気分障害である双極性障害には,高い罹病率と自殺率があります. リチウム塩は,双極性障害の主要な長期治療法であり,抗自殺効果が実証されています.
科学分野:
- 精神科医は精神病を患っている.
- 神経科学は神経科学である.
- 気分障害 気分障害
背景:
- 双極性障害 (躁うつ病) は,有意な罹病率を持つ一般的な重症,再発性気分障害である.
- 生涯における罹患率は1.3-1.6%で,死亡率は一般人口より2〜3倍高い.
- 自殺のリスクはかなり高く,患者の10~20%が自殺で死亡し,ほぼ3分の1が自殺を試みている.
研究 の 目的:
- 双極性障害の特徴と治療法をレビューする.
- 長期的な予防治療の重要性を強調する.
- 異なる薬理学的介入の有効性を議論する.
主な方法:
- 双極性障害に関する既存の文献のレビュー.
- 罹病率,罹病率,死亡率のデータを分析する.
- リチウム,カルバマゼピン,バルプロアートを含む薬理学的治療オプションの評価.
主要な成果:
- 双極性障害は,ヒポマニアから重度の精神病まで,多様な臨床的表れを示します.
- 高い再発率と自殺リスクのため,長期的な予防薬理学的治療は不可欠です.
- リチウム塩は第一線治療であり,有意な抗自殺効果を示しています.
- カーバマゼピンとバルプロアートは,より堅固な証拠のない2番目の選択肢です.
結論:
- 双極性障害は,再発と自殺リスクを軽減するために長期的な管理を必要とします.
- リチウムは,双極性障害の予防治療の黄金基準です.
- 二次線治療のための証拠を強化するために,さらなる研究が必要になる可能性があります.
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