吸入した粒子が人の血液循環に通過する
A Nemmar1, P H M Hoet, B Vanquickenborne
1Laboratory of Pneumology (Lung Toxicology, Katholieke Universiteit Leuven, Leuven, Belgium.
Circulation
|January 30, 2002
まとめ
吸入した超細粒子は急速に血流に入り,大気汚染を説明する可能性がある.
科学分野:
- 環境衛生 環境衛生 環境衛生
- 毒理学 毒理学 毒理学
- 心血管科学の研究について
背景:
- 微粒子の大気汚染は,心血管疾患と関連しています.
- これらの効果の背後にあるメカニズムは不明である.
研究 の 目的:
- 吸入された超細粒子の全身循環を調査する.
- 粒子転移の速度と範囲を決定する.
主な方法:
- 健康なボランティアは, (99m) のテクネチウムラベルを貼った超細い炭素粒子 (<100 nm) を吸入した.
- 血液と身体の分布における放射能は,ガンマカメラを用いて測定した.
- 血液サンプルを薄層クロマトグラフィで分析した.
主要な成果:
- 吸入後1分以内に血液で放射能が検出される.
- 血中放射能のピークは10分から20分間で観察され,60分持続した.
- 血中では粒子結合および酸化テクネチウムが検出され,肝臓は有意な放射能を示した.
結論:
- 吸入された超細い炭素粒子は,急速に全身循環に入り込む.
- この急速な転移が,大気汚染の肺外効果を説明するかもしれない.
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