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Updated: Mar 28, 2026

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
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アクティベーション誘発型シチジンデアミナーゼは,ハイブリドオマスの体性高変異を活性化します

Alberto Martin1, Philip D Bardwell, Caroline J Woo

  • 1Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue Chanin 403, Bronx, New York 10461, USA.

Nature
|February 2, 2002
PubMed
まとめ

ソマティック・ハイパーミューテーション (SHM) は,高親和性抗体を生成する. この研究では,活性化誘発性シチジンデアミナーゼ (AID) が,センターブラスト特異的因子なしでB細胞でSHMを誘発できることを示しています.

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