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Mechanisms of Membrane-bending01:15

Mechanisms of Membrane-bending

The living membranes are flexible due to their fluid mosaic nature; however, their bending into different shapes is an active process regulated by specific lipids and proteins. The membrane bending can be transient as seen in vesicles or stable for a long time as in microvilli. Cells regulate the size, location, and duration of the membrane curvature.
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...
Acid-Catalyzed Ring-Opening of Epoxides02:24

Acid-Catalyzed Ring-Opening of Epoxides

Epoxides that are three-membered ring systems are more reactive than other cyclic and acyclic ethers. The high reactivity of epoxides originates from the strain present in the ring. This ring strain acts as a driving force for epoxides to undergo ring-opening reactions either with halogen acids or weak nucleophiles in the presence of mild acid. The acid catalyst converts the epoxide oxygen, a poor leaving group, into an oxonium ion, a better leaving group, making the reaction feasible. The...
Gyroscope01:02

Gyroscope

A gyroscope is defined as a spinning disk in which the axis of rotation is free to assume any orientation. When spinning, the orientation of the spin axis is unaffected by the orientation of the body that encloses it. The body or vehicle enclosing the gyroscope can be moved from place to place, while the orientation of the spin axis remains the same. This makes gyroscopes very useful in navigation, especially where magnetic compasses cannot be used, such as in crewed and crewless spacecraft,...
Gyroscope: Precession01:24

Gyroscope: Precession

Precession can be demonstrated effectively through a spinning top. If a spinning top is placed on a flat surface near the surface of the Earth at a vertical angle and is not spinning, it will fall over due to the force of gravity producing a torque acting on its center of mass. However, if the top is spinning on its axis, it precesses about the vertical direction, rather than topple over due to this torque. Precessional motion is a combination of a steady circular motion of the axis and the...
Oscillations about an Equilibrium Position01:04

Oscillations about an Equilibrium Position

Stability is an important concept in oscillation. If an equilibrium point is stable, a slight disturbance of an object that is initially at the stable equilibrium point will cause the object to oscillate around that point. For an unstable equilibrium point, if the object is disturbed slightly, it will not return to the equilibrium point. There are three conditions for equilibrium points—stable, unstable, and half-stable. A half-stable equilibrium point is also unstable, but is named so because...
Angle of Twist: Problem Solving01:13

Angle of Twist: Problem Solving

An electric motor applies a torque of 700 N·m to an aluminum shaft, triggering a stable rotation. Two pulleys, B and C, are subjected to torques of 300 N·m and 400 N·m, respectively. The modulus of rigidity is provided as 25 GPa. With the knowledge of the length and diameter of each segment, the twist angle between the two pulleys can be computed. First, a section cut is made between pulleys B and C, and the cut cross-section is analyzed using a free-body diagram. Given that the torque exerted...

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関連する実験動画

Updated: Jul 15, 2026

Method to Measure Tone of Axial and Proximal Muscle
10:41

Method to Measure Tone of Axial and Proximal Muscle

Published on: December 14, 2011

ペプチドピンホイール

David T Kaleta1, Martin F Jarrold

  • 1Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA.

Journal of the American Chemical Society
|February 14, 2002
PubMed
まとめ

電気スプレーによって形成されたペプチドマルチマーは,安定した螺旋状の配列を採用します. これらの構造は,ライシンとアセチル化されたグリシン-アラニンペプチドのジマーとトリマーを含むが,静電相互作用によって協力的に安定化される.

科学分野:

  • バイオ物理化学 バイオ物理化学
  • コンピューティング・ケミストリー
  • 分子生物物理学 分子生物物理学

背景:

  • ペプチドの自己組織化とマルチメリゼーションは,生物系において極めて重要です.
  • ペプチドマルチメアのガス相構造を理解することで,それらの基本的な相互作用の洞察が得られます.

研究 の 目的:

  • 溶解されていないペプチドジマーとトリマーの形状を調査するために,電気スプレーによって形成された.
  • これらのペプチドマルチメーターを支配する安定化力を解明する.

主な方法:

  • ライシンを含むアセチル化されたグリシン-アラニンペプチドの電気スプレー.
  • ガス相構造を検出するためのイオン移動性測定.
  • 形状をモデル化し分析するための分子動力学シミュレーション.

主要な成果:

  • 電気スプレーにより,溶解されていないペプチドジマーとトリマーの有意な信号が生じた.
  • ペプチドトリマーは,ライシンサイドチェーンとヘリックス二極体によって安定させられたヘリクスのピンホイール配列を採用します.
  • ペプチドジメは,V形の螺旋状構造を形成し,協調的静電安定化も示しています.

さらに関連する動画

Magnetically Induced Rotating Rayleigh-Taylor Instability
06:42

Magnetically Induced Rotating Rayleigh-Taylor Instability

Published on: March 3, 2017

High-Temperature and High-Pressure In situ Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy
08:55

High-Temperature and High-Pressure In situ Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy

Published on: October 9, 2020

関連する実験動画

Last Updated: Jul 15, 2026

Method to Measure Tone of Axial and Proximal Muscle
10:41

Method to Measure Tone of Axial and Proximal Muscle

Published on: December 14, 2011

Magnetically Induced Rotating Rayleigh-Taylor Instability
06:42

Magnetically Induced Rotating Rayleigh-Taylor Instability

Published on: March 3, 2017

High-Temperature and High-Pressure In situ Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy
08:55

High-Temperature and High-Pressure In situ Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy

Published on: October 9, 2020

結論:

  • この研究は,ガス相におけるペプチドジマーとトリマーの特定の,安定した螺旋構造を明らかにした.
  • 特にライシンサイドチェーンとヘリックス二極体を含む協同型静電相互作用は,マルチメアの安定性の鍵です.
  • イオン移動と分子ダイナミクスは,ペプチドのマルチマー構造を特徴付けるための効果的なツールです.