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乳がんに関連するホルモン置換療法
Chi-Ling Chen1, Noel S Weiss, Polly Newcomb
1Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, MP702, Seattle, WA 98109, USA.
JAMA
|February 20, 2002
まとめ
長期にわたるホルモン置換療法 (HRT) の使用は,乳がんの危険性を高め,特に葉帯腫瘍の危険性を高めます. このリスクは,エストロゲン単独療法と併用療法の両方で明らかです.
科学分野:
- 腫瘍学 腫瘍学
- エンドクリノロジー エンドクリノロジー
- エピデミオロジー エピデミオロジー
背景:
- 長期にわたるホルモン置換療法 (HRT) の使用は,乳がんのリスクの増加と関連しています.
- 以前の研究では,この関連ががんの組織学によって変化するかどうかを広範に調査していない.
研究 の 目的:
- HRTと乳がんリスクとの関連がHRT製剤によって異なるかどうかを調査する.
- 乳がんリスクに対するHRTの影響が,異なる組織学的がんタイプによって異なるかどうかを判断する.
主な方法:
- 50歳から74歳までの閉経後の女性を対象に,ネスドケース・コントロール研究が行われました.
- 乳がんの発生率とタイプは,薬局記録を使用してHRTの使用期間に基づいて分析されました.
主要な成果:
- 最近長期にわたるHRT使用 (エストロゲン単独または併用) は,乳がん全体の発生率を60~85%増加させた.
- 長期にわたるHRT使用と組み合わせた治療は,特に,側頭葉乳がんのリスクの増加と関連していました.
- 長期にわたるHRT使用は,非球状乳がんのリスクの50%増加と関連していました.
結論:
- 最近,長期にわたるHRTの使用は,乳がんのリスクの増加と関連しています.
- 増加したリスクは,乳房の葉状腫瘍において特に顕著である.
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