認知的に刺激的な活動への参加とアルツハイマー病の発生リスク
Robert S Wilson1, Carlos F Mendes De Leon, Lisa L Barnes
1Rush Alzheimer's Disease Center, 1645 W Jackson Blvd, Suite 675, Chicago, IL 60612, USA. rwilson@rush.edu
JAMA
|February 20, 2002
まとめ
精神的に刺激的な活動に従事することは,アルツハイマー病 (AD) のリスクを低下させる可能性があります. この研究では,頻繁な認知活動が,ADを発症するリスクの33%低下と関連していることが判明しました.
科学分野:
- 神経科学は神経科学である.
- ゲロントロジーはゲロントロジーの学科です.
- 公衆衛生は公衆衛生である.
背景:
- 認知を刺激する活動は,アルツハイマー病 (AD) のリスクを軽減すると仮定されています.
- この関連に関する将来的なデータは限られている.
研究 の 目的:
- 認知活動への頻繁な参加とADを発症するリスクとの関連を調査する.
- 高度な認知活動がADに対して保護的であるという仮説を検証する.
主な方法:
- 認知症のない801人の年配のカトリックの修道女,司祭,修道士の縦断的なコホート研究.
- 初期認知活動頻度は,検証された複合スコアを使用して測定されました.
- 参加者はADの診断と認知機能の変化について平均4.5年間追跡された.
主要な成果:
- 認知活動スコアの1ポイントの上昇は,ADリスクの33%の減少と関連していました (HR, 0.67).
- この関連性は,年齢,性別,教育,その他の要因を調整した後も依然として有意であった.
- 認知活動の増加は,グローバル認知,作業記憶,知覚速度の低下とも相関していた.
結論:
- 認知的に刺激的な活動に頻繁に参加することは,アルツハイマー病のリスクの低下と関連しています.
- 認知の関与を促進することは,ADの予防のための実行可能な戦略かもしれません.
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