ペロキシソーム増殖器活性化受容体アルファ遺伝子は,運動と高血圧への反応として左心房の成長を調節する
Yalda Jamshidi1, Hugh E Montgomery, Hans-Werner Hense
1Centre for Cardiovascular Genetics, Department of Medicine, University College London Medical School, London, UK.
Circulation
|February 28, 2002
まとめ
ペロキシソーム増殖器活性化受容体アルファ (PPARalpha) 遺伝子の遺伝的変異は,運動と高血圧への反応として左心室の成長に影響を与え,左心室縮 (LVH) の発達に影響を与えます.
科学分野:
- 心血管生理学 心血管の生理学
- 分子遺伝学 分子遺伝学
- 人間の生理学 人間生理学
背景:
- 左心室多動症 (LVH) は,増加した心臓の作業負荷に対する適応反応ですが,その分子メカニズムは不明です.
- 脂肪酸の酸化における遺伝的欠陥は,早期発症の心筋縮と関連しています.
- ペロキシソーム増殖器活性化受容体アルファ (PPARalpha) は,心筋脂肪酸の酸化を調節し,心筋縮の間にダウンレギュレーションされます.
研究 の 目的:
- 人間の左心室の成長におけるPPARalpha遺伝子変異の役割を調査する.
- PPARalphaが運動と高血圧への反応としてLVHに影響を与えるかどうかを判断する.
主な方法:
- 身体訓練を受けていたイギリス陸軍の男性新兵144人を調査した.
- MONICAアウグスブルク研究に参加した1,148人のエコーカルディオグラフィのデータを分析した.
- 左心室 (LV) 質量に対するPPARalpha遺伝子のイントロン7におけるG/C多形化の影響を評価した.
主要な成果:
- PPARalpha遺伝子のG/Cポリモルフィズムが,運動への反応としてLVの成長に有意な影響を及ぼした (P=0.009).
- Cアレルを持つ個人は,Gアレルホモジゴトと比較して,LVマスの増加が大きいことを示しました.
- Cアレルホモジゴットは,特に高血圧の被験者において,より高いLV質量とLVHのより高い流行を示した.
結論:
- PPARalpha遺伝子の変異は,運動と高血圧による人間の左心室の成長に影響します.
- PPARalphaの影響を受ける心筋基板の不適正な利用は,LVHの病原化に寄与する可能性があります.
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