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Updated: Jul 6, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

水中のオフセットpi-pi スタックされた相互作用における予期せぬ置換物効果

Mark J Rashkin1, Marcey L Waters

  • 1Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599-3290, USA.

Journal of the American Chemical Society
|February 28, 2002
PubMed
まとめ

この研究では,代用ピリジニウムブロミドの回転障壁を測定するために,ダイナミックNMRを用いた. 電子陰性メタ置換剤は,回転障壁を著しく増加させ,タンパク質におけるより強いオフセットスタッキング相互作用を示した.

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