初期重症と関連して5年間の心臓死亡リスクと,心筋梗塞後のうつ症状の1年間の変化
François Lespérance1, Nancy Frasure-Smith, Mario Talajic
1Department of Psychiatry, University of Montreal and McGill University, Canada. francois.lesperance@umontreal.ca
Circulation
|March 6, 2002
まとめ
心筋梗塞 (MI) の後のうつ症状は,長期的な心臓死亡率と関連しています. 初期的なうつ状態のレベルが高くなるということは,症状が時間の経過とともに変化するかどうかにかかわらず,より悪い結果を予測します.
科学分野:
- 心臓病学 心臓病学
- 精神科医は精神病を患っている.
- 公衆衛生は公衆衛生である.
背景:
- 以前の研究では,うつ病の症状と心筋梗塞 (MI) 以後の心臓死亡率が関連していた.
- 以前の研究は,用量反応関係を評価したり,うつ病を縦断的に評価したりしませんでした.
研究 の 目的:
- 抑うつ症状と心臓発作後の長期的な心臓死亡率の投与反応関係を調査する.
- 入院中に評価されたうつ病の症状の予後値と,1年間の追跡期間での予後値を比較する.
主な方法:
- ベック・デプレッション・インベントリー (BECK Depression Inventory) を,入院時に,そして1年後に,心筋梗塞後の896人の患者に投与した.
- メディケアデータを用いて確認された5年生存率.
- 心臓病の重症度測定のために制御されています.
主要な成果:
- 入院時のうつ病症状と心臓疾患による死亡率の間に,長期にわたる有意な投与量反応関係が観察されました.
- 入院時のうつ病スコアは,1年間のスコアよりも長期的な死亡率と強く関連していました.
- 症状の改善は,軽度のうつ病の患者にのみ効果があり,より高い初期スコアはより悪い予後を予測しました.
結論:
- 入院うつ病レベルは,1年レベルよりも,特に中等から重度のうつ病において,MI後の長期的な生存にとってより重要である.
- 鬱病と死亡率を結びつける心臓血管のメカニズムは,一部の患者では永久に続く可能性があります.
- 心臓発作後のうつ病の早期評価と管理は,長期的な心疾患の改善に不可欠です.
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