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ステレオ制御による (+) -ビンブラスティンの全合成
Satoshi Yokoshima1, Toshihiro Ueda, Satoshi Kobayashi
1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Journal of the American Chemical Society
|March 7, 2002
まとめ
研究者は, (+) -ビンブラスティンのステレオ制御された全合成を達成しました. これには,新しいインドル合成と,重要なインドル単位のステレオ選択的結合が含まれていました.
科学分野:
- 有機化学 オーガニック・ケミストリー
- 合成化学 合成化学とは
- 薬用化学 薬用化学について
背景:
- ヴィンブラスティンは,天然の源から得られた重要な抗がん剤です.
- トータル合成は,限られた天然供給の代替手段である.
研究 の 目的:
- (+) -ビンブラスティンのステレオ制御された全合成を開発する.
- インドル単位の準備のための新しい方法を確立する.
主な方法:
- ティオアニリドの根源的なサイクリングによる新しいインドール合成.
- 2つの異なるインドル単位のステレオ選択的結合.
主要な成果:
- (+) ヴィンブラスティンのステレオ制御による全合成が成功しました.
- 必要なインドル前駆物質の効率的な製造.
結論:
- 開発された合成経路は, (+) -ビンブラスティンへの有効な経路を提供します.
- 新型インドール合成は,複雑な分子構造に適用できます.
関連する概念動画
Control Volume and System Representations
Two key frameworks are employed to analyze mass, energy, and momentum transfer: the control volume approach and the system approach. These frameworks offer different perspectives, depending on whether the focus is on a specific region in space (control volume approach) or a defined mass of fluid (system approach).
The control volume approach considers a stationary region in space through which fluid flows. This region is bounded by a control surface. For instance, in the case of water flowing...
The control volume approach considers a stationary region in space through which fluid flows. This region is bounded by a control surface. For instance, in the case of water flowing...
Conservation of Mass in Finite Cotrol Volume
The principle of conservation of mass is a fundamental law in fluid mechanics and is applied using the continuity equation. We apply the concept to a finite control volume to derive the continuity equation.
A system is defined as a collection of unchanging contents, and the conservation of mass states that a system's mass is constant.
A system is defined as a collection of unchanging contents, and the conservation of mass states that a system's mass is constant.
Conservation of Mass in Fixed, Nondeforming Control Volume
The principle of conservation of mass is fundamental in fluid dynamics and is crucial for analyzing flow within fixed control volumes, such as pipes or ducts. This principle states that the total mass within a control volume remains constant unless altered by the inflow or outflow of mass through the control surfaces. This results in a vital relationship for steady, incompressible flow where the mass entering a system equals the mass leaving it.
In the case of a sewer pipe, which can be modeled...
In the case of a sewer pipe, which can be modeled...
Conservation of Mass in Moving, Nondeforming Control Volume
Stormwater detention basins are essential in managing runoff during heavy rainfall, particularly in urban areas where impervious surfaces increase the risk of flooding. Understanding the conservation of mass in these systems allows engineers to optimize basin performance, balancing inflow, outflow, and water storage.
In the context of a detention basin, the conservation of mass states that the total mass of water entering the basin must equal the mass leaving the basin plus any accumulation of...
In the context of a detention basin, the conservation of mass states that the total mass of water entering the basin must equal the mass leaving the basin plus any accumulation of...
Linear Momentum in Control Volume
Newton's second law is applied to obtain the linear momentum in a control volume in a fluid system. According to this law, the rate of change of linear momentum is equal to the sum of external forces acting on the system. When a control volume matches the fluid system at a specific moment, the forces acting on both are identical. Reynolds transport theorem helps explain this by breaking down the system's linear momentum into two components: the rate of change of linear momentum within the...
Conservation of Energy in Control Volume
Consider a turbine operating under steady-flow conditions. The control volume is drawn around the turbine, with fluid entering at one point and exiting at another. The turbine extracts energy from the fluid, which performs mechanical work (shaft work).
For steady flow systems, the time derivative of the stored energy becomes zero since there is no energy accumulation within the control volume. This simplifies the energy equation to:
For steady flow systems, the time derivative of the stored energy becomes zero since there is no energy accumulation within the control volume. This simplifies the energy equation to:

