免疫能力のある小児における原発ヒトヘルペスウイルス8感染
Massimo Andreoni1, Loredana Sarmati, Emanuele Nicastri
1Department of Public Health and Cellular Biology, University Tor Vergata, Via Montpellier 1, 00133 Rome, Italy. andreoni@uniroma2.it
JAMA
|March 12, 2002
まとめ
ヒトヘルペスウイルス8 (HHV-8) による小児原発感染は,発熱性マキュロパプル発疹を引き起こす可能性があります. 唾液検査でHHV-8のDNAが確認され,これは小児の集団における主要な感染経路であることを示唆しています.
科学分野:
- ウイルス学 ウイルス学 ウイルス学
- 小児科は小児科です.
- エピデミオロジー エピデミオロジー
背景:
- ヒトヘルペスウイルス8 (HHV-8) は,免疫抑制の成人において,カポシ肉腫およびリンパ増殖性疾患を引き起こすことが知られている.
- 免疫能力のある個人,特に子供におけるHHV-8の臨床的表れは,ほとんど不明のままである.
研究 の 目的:
- 免疫力のある小児における症状性プライマリーHHV-8感染を調査する.
- この年齢層におけるHHV-8感染に関連する疫学的およびウイルス学的要因を特定する.
主な方法:
- エジプトのアレクサンドリアの小児救急病院で,前向きなコホート研究が行われました.
- 原因不明の発熱性疾患を患った1歳から4歳までの86人の子どもを評価した.
- 血清検査と血液と唾液のサンプルでのPCRは,危険因子データの収集とともに,HHV-8を検出するために使用されました.
主要な成果:
- 子供の41.9%がHHV-8に陽性で,そのうち38.9%でDNAが検出され,主に唾液に検出されました.
- HHV-8感染は,複数の子供と密接な接触と冬季の緊急診療所訪問と有意に関連していました.
- 6人の子どもは5人の症例で発熱性マキュロパプル発疹によって特徴づけられたHHV-8原発感染の兆候を示した.
結論:
- 免疫不全児におけるHHV-8原発感染は,発熱性マキュロパプル発疹を伴う可能性があります.
- 唾液中のHHV-8DNAの検出は,小児の集団における主要な感染経路としての役割をサポートしています.
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