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Updated: Jun 6, 2026

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling
07:49

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling

Published on: August 3, 2018

腫瘍死滅因子-αは,血管の滑らかな筋肉におけるインスリン類似成長因子-1とインスリン類似成長因子結合タンパク質-3の発現を調節する

A Anwar1, A A Zahid, K J Scheidegger

  • 1Division of Cardiology, University Hospital of Geneva, Switzerland.

Circulation
|March 13, 2002
PubMed
まとめ

腫瘍死滅因子アルファ (TNF-alpha) は,血管の滑らかな筋肉細胞におけるインスリン類似成長因子-1 (IGF-1) を減らし,IGF結合タンパク質-3 (IGFBP-3) を増加させる. TNF-αによるIGF-1のダウンレギュレーションは,冠動脈症候群におけるプラークの不安定性を促進する可能性があります.

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Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells06:54

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