寒い刺激とメントールを感知するTRPチャネルです
Andrea M Peier1, Aziz Moqrich, Anne C Hergarden
1Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
Cell
|March 15, 2002
まとめ
研究者らは,新種の冷却感知イオンチャネルであるTRPM8を特定した. この一時受容体ポテンシャル (TRP) チャンネルは,特定の感覚ニューロンで発現し,熱刺激を検出するTRPチャンネルの既知の役割を拡張します.
科学分野:
- 神経科学は神経科学である.
- 分子生物学は分子生物学である.
- 感覚生理学 感覚生理学とは
背景:
- 皮膚の感覚神経は,熱エネルギーの変化を検知すると考えられています.
- 熱受容を媒介する特定の分子は,ほとんど不明のままである.
- TRPチャネルであるヴァニロイド受容体1 (VR1) は,高温によって活性化されます.
研究 の 目的:
- 新しいイオンチャネルであるTRPM8をクローンし,特徴づけること.
- 感覚神経細胞の機能におけるTRPM8の役割を調査する.
- 冷たい感覚に関与する分子を特定するために.
主な方法:
- TRPM8遺伝子のクローニング.
- TRPM8チャンネル特性の特徴.
- 感覚神経細胞における表現分析.
- TRPM8.8を過剰発現する細胞を用いた機能分析.
主要な成果:
- TRPM8はクローン化され,VR1.1の遠い親戚として特徴づけられました.
- TRPM8は,痛みと温度を感知するニューロンのサブセットで特定の発現を示す.
- TRPM8を過剰に発現する細胞は,低温とメントールによって活性化されます.
結論:
- TRPM8は,冷たい感受性イオンチャネルとして特定されています.
- この発見は,体感覚検出におけるTRPチャネルの役割の拡大を意味しています.
- TRPM8は,冷たい刺激の知覚における重要な分子を表しています.
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