喘息患者および非喘息患者におけるライノウイルス感染症の頻度,重症度,および持続時間:縦断的なコホート研究
Jonathan M Corne1, Clare Marshall, Sandra Smith
1University Medicine, Southampton General Hospital, Southampton, UK. Jonathan.Corne@mail.qmcuh-tr.trent.nhs.uk
Lancet (London, England)
|March 19, 2002
まとめ
アトピー性喘息の個人は,リノウイルス感染症のリスクが高くありません. しかし,彼らはより頻繁で重症で長期にわたる下呼吸器管 (LRT) 感染症と症状を経験します.
科学分野:
- 呼吸器医学とは
- 感染症 感染症は感染症です.
- 免疫学 免疫学とは
背景:
- リノウイルス感染症は,喘息の悪化を誘発することが知られている.
- 一つの仮説は,喘息の個人にライノウイルスに対する感受性の増加を示唆した.
研究 の 目的:
- アトピー性喘息の患者と健康な人の間で,ライノウイルス感染に対する感受性を比較する.
- 感染リスク,重症度,持続時間における差異を評価する.
主な方法:
- 76組の同居カップル (喘息のある1組,健康な1組) を募集しました.
- 参加者が自己報告した呼吸器症状 (URT/LRT) と毎日測定したピーク呼吸器流量.
- 鼻吸液は,ライノウイルス検出のために週2回収集され,混合モデルでは感染リスクが分析されました.
主要な成果:
- リノウイルス検出率は類似した:喘息群では10.1%,健康群では8.5% (OR 1.15,95%CI 0.71-1.87).
- 上部呼吸器管 (URT) 感染の頻度,重症度,または持続時間において有意な差異はありません.
- 下呼吸器系 (LRT) 感染症は,より頻繁であり,喘息グループではより重症で長く続く症状と関連していました.
結論:
- アトピー性喘息は,ライノウイルス感染症のリスクを増加させない.
- 喘息の個人は,リノウイルス感染症の後により頻繁なLRT感染症とより重篤で長期のLRT症状を経験します.
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