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Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
Published on: October 16, 2010
インスリン抵抗性と内生性酸化窒素合成酵素阻害剤の関係
Markus C Stühlinger1, Fahim Abbasi, James W Chu
1Division of Cardiovascular Medicine, Stanford University School of Medicine, Falk Cardiovascular Research Center, 300 Pasteur Dr, Stanford, CA 94305, USA.
JAMA
|March 21, 2002
まとめ
インスリン抵抗性は,内皮機能不全のマーカーである非対称性ダイメチルルギニン (ADMA) レベルが高いことと関連しています. ロシグリタゾンによる治療は,インスリン感受性を改善し,ADMA濃度を著しく低下させた.
科学分野:
- 心血管研究 循環器科の研究
- メタボリックシンドローム研究 メタボリックシンドローム研究
- エンドクリノロジー エンドクリノロジー
背景:
- アシンメトリックジメチラーギニン (ADMA) の上昇は,内皮機能不全と心血管疾患のリスクに関連しています.
- ADMAとメタボリックシンドローム,特にインスリン抵抗性との関連については,さらなる解明が必要である.
研究 の 目的:
- インスリン感受性とプラズマのADMA濃度との関係を調査する.
- インスリン感受性を高める薬剤がADMA濃度を調節できるかどうかを判断する.
主な方法:
- 64人の健康なボランティアを対象とした非ランダム化対照試験のコンポーネントを含む横断的な研究.
- インスリン感受性は,インスリン抑制テストを使用して評価されました.
- ロシグリタゾンは,インスリン抵抗性のある被験者に投与され,インスリン感受性およびADMAレベルの変化を評価しました.
主要な成果:
- 血のADMA濃度は,インスリン媒介によるグルコース排出の低下とトリグリセリド濃度の上昇と正に相関していた.
- インスリン抵抗性は,高血圧に関係なく,ADMA濃度の上昇と関連していました.
- ロシグリタゾン治療はインスリン感受性を改善し,プラズマADMA濃度 (1.50〜1.05μmol/L) を著しく低下させた.
結論:
- インスリン抵抗性と血のADMA濃度の上昇との間に有意な関連性がある.
- ロシグリタゾンによるインスリン感受性の薬理学的強化は,ADMA濃度を効果的に低下させる.
- 増加したADMAは,インスリン抵抗性の個人に観察された内皮機能不全に役割を果たす可能性があります.
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