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Updated: Jul 13, 2026

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
07:00

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene

Published on: April 1, 2019

ウォルファリン療法中のCYP2C9遺伝子変異と抗凝固関連のアウトカムとの関連

Mitchell K Higashi1, David L Veenstra, L Midori Kondo

  • 1University of Washington, Department of Pharmacy, Box 357630, Health Sciences Bldg, Room H-375A, Seattle, WA 98195, USA.

JAMA
|April 3, 2002
PubMed
まとめ

CYP2C9 (サイトクロームP450 2C9) の遺伝子変異は,ウォルファリンを服用している患者において,過剰抗凝固および出血のリスクを高めます. これらのCYP2C9変異のスクリーニングは,ワーファリンの投与量をパーソナライズし,薬剤の副作用を軽減するのに役立ちます.

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