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Updated: Jul 19, 2026

The Importance of Correct Protein Concentration for Kinetics and Affinity Determination in Structure-function Analysis
19:16

The Importance of Correct Protein Concentration for Kinetics and Affinity Determination in Structure-function Analysis

Published on: March 17, 2010

生化学的な協力性における構成エントロピーの役割

Sutjano Jusuf1, Patrick J Loll, Paul H Axelsen

  • 1Department of Pharmacology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104-6084, USA.

Journal of the American Chemical Society
|April 4, 2002
PubMed
まとめ

バンコマイシンと関連するグリコペプチド抗生物質の相互作用は,分子構造の変化なしに起こる可能性があります. この研究は,変化した分子振動だけで,これらの協力現象を駆動することができると示しています.

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Cofactors and Coenzymes

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The use of enzymes by humans dates to 7000 BCE. Humans first used enzymes to ferment sugars and produce alcohol without knowing that this was an enzyme-catalyzed reaction. Wilhelm Kuhne coined the term 'enzyme' in 1877 from the Greek words ‘en’ meaning ‘in’ or ‘within’ and ‘zyme’ meaning ‘yeast.’
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Cofactors and Coenzymes

Enzymes are proteins made of amino acids. The functional group of each constituent amino acid catalyzes a wide variety of chemical reactions via ionic interactions or acid-base reactions. However, amino acids cannot catalyze oxidation-reduction and group transfer reactions and need to be aided by non-protein components called cofactors. Cofactors are also referred to as the chemical teeth of an enzyme.
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