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Updated: Jun 16, 2026

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
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DNMT1とDNMT3bは,ヒトがん細胞の遺伝子を沈黙させるために協力しています

Ina Rhee1, Kurtis E Bachman, Ben Ho Park

  • 1The Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

Nature
|April 5, 2002
PubMed
まとめ

人間の癌細胞は,DNAメチルトランスフェラーゼ1 (DNMT1) とDNMT3Bという2つの重要な酵素に依存し,DNAメチル化と遺伝子サイレンスを行う. 両方への干渉はメチル化を大幅に低下させ,癌細胞の成長に影響を与えます.

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