1983年から1997年の米国におけるダウン症候群に関連する死亡率:人口ベースの研究
Quanhe Yang1, Sonja A Rasmussen, J M Friedman
1National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, 4770 Buford Highway, MS F-45, Atlanta, GA 30341, USA. qyang@cdc.gov
Lancet (London, England)
|April 9, 2002
まとめ
ダウン症候群患者の死亡年齢の平均は著しく増加したが,人種差は依然として残っている. 癌の発生率は,白血病を除いて著しく低く,潜在的な保護要因を示唆しています.
科学分野:
- 遺伝学と人間の健康について
- エピデミオロジー エピデミオロジー
- 医学研究 医学研究
背景:
- ダウン症候群は知的障害の主な原因である.
- ダウン症候群患者の死亡率と併発症に関するデータは限られている.
研究 の 目的:
- ダウン症候群患者の死亡率の傾向と一般的な併発症を分析する.
- 生存率とがん発生率における人種差異を調査する.
主な方法:
- 1983年から1997年の米国死亡証明書のデータを活用した.
- 死亡時の平均年齢と標準化された死亡確率比率 (SMORs) を計算した.
主要な成果:
- 死亡時の平均年齢は1983年から1997年の間に25歳から49歳に上昇した.
- 生まれながらの心不全,認知症,甲状腺機能低下症は,非常に一般的な併発症でした.
- 白血病を除くがんの発生率は,ダウン症候群の個体では予想より著しく低かった.
結論:
- 生存における人種差異については,さらなる調査が必要である.
- ダウン症候群における癌に対する潜在的な保護機構は,おそらく21染色体遺伝子または細胞プロセスを含む探索を正当化します.
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