ネズミのクレマスター筋肉のマイクロ容器間の酸素伝達のイメージング
Hirosuke Kobayashi1, Naosada Takizawa
1Department of Medicine, School of Medicine, and Information Science Center (N.T.), Kitasato University, Kanagawa, Japan. hiro@kitasato-u.ac.jp
Circulation
|April 10, 2002
まとめ
この研究では,ネズミのクレマスター筋肉の微小血管における酸素飽和度 (SO2) を視覚化し,隣接し交差する動脈,静脈,毛細血管の間の酸素の移転を明らかにした.
科学分野:
- 生理学 生理学とは
- 微循環というマイクロ循環です.
- 酸素輸送 酸素輸送
背景:
- マイクロ血管の近接は,酸素の伝達のための複雑な空間的関係を作り出します.
- マイクロ血管の酸素飽和度 (SO2) のin vivoマッピングはこれまで行われていなかった.
研究 の 目的:
- マイクロ容器内の in vivo 酸素飽和度 (SO2) レベルを視覚化およびマッピングします.
- ネズミのクレマスター筋肉の微小血管間の酸素伝達ダイナミクスを調査するために.
主な方法:
- 3 つの光学フィルターと冷却されたCCDカメラを備えたマイクロスペクトロフォトメトリーを使用しました.
- 動脈小節,静脈小節,毛細血管におけるSO2濃度の擬色画像を生成した.
- ネズミのクレマスター筋肉のノルモキシアとヒポキシア下で酸素プロファイルを分析した.
主要な成果:
- SO2レベルは,血管壁の近くでは低く,中央線では高かった.
- ペアリングした静脈は,動脈管の近くのSO2レベルが高くなりました.
- SO2レベルはマイクロ血管を横断する毛細血管で変化し,動脈小管が静脈を横断した後に変化が観察され,その逆も同様である.
結論:
- 血管内 SO2 ビジュアライゼーションは,ペアリングされた微小容器と交差する微小容器の間の酸素転送を示唆しています.
- 動脈小節から血管や組織に毛細血管経由で酸素を運ぶモデルが提案されています.
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