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Olfaction01:25

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...

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Updated: Jun 30, 2026

Imaging Pheromone Sensing in a Mouse Vomeronasal Acute Tissue Slice Preparation
09:31

Imaging Pheromone Sensing in a Mouse Vomeronasal Acute Tissue Slice Preparation

Published on: December 6, 2011

フェロモン,嘔吐鼻機能,およびジェンダー特有の行動

Eric B Keverne1

  • 1Sub-Department of Animal Behaviour, University of Cambridge, Madingley, CB3 8AA, Cambridge, United Kingdom. ebk10@cus.cam.ac.uk

Cell
|April 17, 2002
PubMed
まとめ
この要約は機械生成です。

TRP2イオンチャネルを持たないマウスは,異なった行動を示し,性特有の社会的相互作用と繁殖における鼻器官の重要な役割を明らかにする.

さらに関連する動画

Imaging Neuronal Responses in Slice Preparations of Vomeronasal Organ Expressing a Genetically Encoded Calcium Sensor
11:26

Imaging Neuronal Responses in Slice Preparations of Vomeronasal Organ Expressing a Genetically Encoded Calcium Sensor

Published on: December 6, 2011

In-depth Physiological Analysis of Defined Cell Populations in Acute Tissue Slices of the Mouse Vomeronasal Organ
10:11

In-depth Physiological Analysis of Defined Cell Populations in Acute Tissue Slices of the Mouse Vomeronasal Organ

Published on: September 10, 2016

関連する実験動画

Last Updated: Jun 30, 2026

Imaging Pheromone Sensing in a Mouse Vomeronasal Acute Tissue Slice Preparation
09:31

Imaging Pheromone Sensing in a Mouse Vomeronasal Acute Tissue Slice Preparation

Published on: December 6, 2011

Imaging Neuronal Responses in Slice Preparations of Vomeronasal Organ Expressing a Genetically Encoded Calcium Sensor
11:26

Imaging Neuronal Responses in Slice Preparations of Vomeronasal Organ Expressing a Genetically Encoded Calcium Sensor

Published on: December 6, 2011

In-depth Physiological Analysis of Defined Cell Populations in Acute Tissue Slices of the Mouse Vomeronasal Organ
10:11

In-depth Physiological Analysis of Defined Cell Populations in Acute Tissue Slices of the Mouse Vomeronasal Organ

Published on: September 10, 2016

科学分野:

  • 神経科学は神経科学である.
  • 行動生物学 行動生物学
  • センサリーシステム センサリーシステム

背景:

  • 嘔吐鼻臓器 (Vomeronasal organ,VNO) は,フェロモンの検出に関与する感覚構造である.
  • TRP2イオンチャネルはVNOで発現し,感覚伝導に不可欠です.

研究 の 目的:

  • 吐口鼻器官の機能におけるTRP2イオンチャネルの役割を調査する.
  • ネズミの性別特異性性行動に対するVNOとTRP2の貢献を明らかにする.

主な方法:

  • TRP2イオンチャネルが欠けているマウスの行動分析 (TRP2ノックアウトマウス).
  • 制御された実験環境における社会的および性的行動の評価.

主要な成果:

  • TRP2ノックアウトマウスは,野生型の対照群と比較して,ジェンダー特異的な性的行動が著しく変化している.
  • これらの行動的欠陥は,VNO媒介の感覚入力が生殖行動の調節における重要な役割を強調しています.

結論:

  • TRP2イオンチャネルは,正常な吐口鼻器官機能に不可欠である.
  • TRP2によって媒介される嘔吐鼻臓器のシグナル伝達は,ジェンダー特有の性的行動の正確な実行に不可欠です.