関連する実験動画

Updated: Jul 18, 2026

Differentiation of Embryonic Stem Cells into Oligodendrocyte Precursors
08:11

Differentiation of Embryonic Stem Cells into Oligodendrocyte Precursors

Published on: May 19, 2010

bHLH転写因子OLIG2とOLIG1のカップルは,ニューロンおよびグリアサブタイプの特異性です

Qiao Zhou1, David J Anderson

  • 1Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125, USA.

Cell
|April 17, 2002
PubMed
まとめ

Olig1とOlig2の転写因子は,モトニューロンとオリゴデンドロサイトの生成を制御し,脊髄の発達に不可欠です. その欠如は,異なる細胞型の生成につながり,中枢神経系細胞の特異化のための組み合わせコードを明らかにします.

さらに関連する動画

Identifying Transcription Factor Olig2 Genomic Binding Sites in Acutely Purified PDGFRα+ Cells by Low-cell Chromatin Immunoprecipitation Sequencing Analysis12:29

Identifying Transcription Factor Olig2 Genomic Binding Sites in Acutely Purified PDGFRα+ Cells by Low-cell Chromatin Immunoprecipitation Sequencing Analysis

Published on: April 16, 2018

Dissection and Isolation of Murine Glia from Multiple Central Nervous System Regions08:00

Dissection and Isolation of Murine Glia from Multiple Central Nervous System Regions

Published on: June 4, 2020

関連する概念動画

Glial Cells01:04

Glial Cells

Overview
Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...