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関連する概念動画

Contact-dependent Signaling01:19

Contact-dependent Signaling

Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
Glial Cells01:04

Glial Cells

Overview
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Neuromuscular Junction01:19

The Neuromuscular Junction

The nervous system consists of complex motor neuron circuits, including upper motor neurons originating from the cerebral cortex and lower motor neurons starting in the spinal cord, coordinating both voluntary and involuntary movements. Among these, somatic motor neurons activate skeletal muscles and are classified into alpha, beta, and gamma types. Alpha neurons are vital for voluntary movement coordination, while gamma neurons adjust muscle spindle sensitivity, and the function of beta...
Nervous Tissue: Myelin01:25

Nervous Tissue: Myelin

The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...

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関連する実験動画

Updated: May 21, 2026

Preparation of Rat Oligodendrocyte Progenitor Cultures and Quantification of Oligodendrogenesis Using Dual-infrared Fluorescence Scanning
11:11

Preparation of Rat Oligodendrocyte Progenitor Cultures and Quantification of Oligodendrogenesis Using Dual-infrared Fluorescence Scanning

Published on: February 17, 2016

オリグ機能の共通の発達要件は,モーターニューロン/オリゴデンドロサイト接続を示す.

Q Richard Lu1, Tao Sun, Zhimin Zhu

  • 1Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.

Cell
|April 17, 2002
PubMed
まとめ

Olig1およびOlig2遺伝子は,オリゴデンドロ細胞の発達と神経パターンの形成に不可欠です. 遺伝的破壊は,中枢神経系におけるそれらの特定の役割を明らかにし,ニューロンとオリゴデンドロサイトの特異性に影響を与えます.

さらに関連する動画

Generation of Oligodendrocytes and Oligodendrocyte-Conditioned Medium for Co-Culture Experiments
09:05

Generation of Oligodendrocytes and Oligodendrocyte-Conditioned Medium for Co-Culture Experiments

Published on: February 9, 2020

Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions
10:53

Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions

Published on: November 9, 2020

関連する実験動画

Last Updated: May 21, 2026

Preparation of Rat Oligodendrocyte Progenitor Cultures and Quantification of Oligodendrogenesis Using Dual-infrared Fluorescence Scanning
11:11

Preparation of Rat Oligodendrocyte Progenitor Cultures and Quantification of Oligodendrogenesis Using Dual-infrared Fluorescence Scanning

Published on: February 17, 2016

Generation of Oligodendrocytes and Oligodendrocyte-Conditioned Medium for Co-Culture Experiments
09:05

Generation of Oligodendrocytes and Oligodendrocyte-Conditioned Medium for Co-Culture Experiments

Published on: February 9, 2020

Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions
10:53

Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions

Published on: November 9, 2020

科学分野:

  • 神経科学は神経科学である.
  • 発達生物学 発達生物学とは
  • 遺伝学 遺伝学とは

背景:

  • オリゴデンドロサイト系遺伝子のOlig1とOlig2は,基本的なヘリックス・ループ・ヘリックス (bHLH) タンパク質をコードする.
  • これらの遺伝子は神経原産体で共発現し,中枢神経系 (CNS) の初期発達における役割を示唆しています.

研究 の 目的:

  • オリゴデンドログリアと中枢神経系の祖先におけるOlig1とOlig2の発達的役割を調査する.
  • 多能原始体からオリゴデンドロサイト発達の遺伝的要件を解明する.

主な方法:

  • マウスにおけるOlig1とOlig2の標的遺伝子破壊.
  • 神経原産体の発達と細胞運命をマッピングする分析.

主要な成果:

  • Olig2は,脊髄におけるオリゴデンドロサイトとモーターニューロンの特異化に不可欠です.
  • Olig1は,特に脳におけるオリゴデンドロ細胞の発達と成熟に重要な役割を果たします.
  • 両方のオリグ遺伝子は神経パターン形成に寄与しますが,どちらもアストロサイト発育には必要ありません.
  • 運命マッピングは,オリゴデンドロサイトは,ニューロンを生成するオリグ指定の原始体から発生することを示しています.

結論:

  • Olig1とOlig2は,オリゴデンドロサイト系統の発達と中枢神経系のパターニングの重要なレギュレーターです.
  • これらの遺伝子は,ニューロンとオリゴデンドロサイトの両方に起因する特定の祖先集団を定義します.