N-グリコシル結合の安定性に関する理論的研究:なぜN7-プラチナ化は浄化を促進しないのか?

Mu-Hyun Baik1, Richard A Friesner, Stephen J Lippard

  • 1Department of Chemistry, Columbia University, New York, New York 10027, USA.

まとめ

プロトネーションはグアノシン浄化を加速するが,シスプラチン結合は加速しない. 計算分析により,DNAの安定性とシスプラチン相互作用に影響を与える電子的差異が明らかになりました.

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