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Updated: Jun 11, 2026

Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro
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RANKLは,インターフェロンベータのc-Fos依存誘導により,骨の恒常性を維持する

Hiroshi Takayanagi1, Sunhwa Kim, Koichi Matsuo

  • 1Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

Nature
|April 19, 2002
PubMed
まとめ

NF-kappaBリガンド (RANKL) の受容体活性化剤は,骨格細胞の前駆体におけるインターフェロン-β (IFN-β) を誘導する. このIFN-βは,骨格細胞の分化を阻害し,骨の恒常性のための新しい調節経路を明らかにします.

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