大規模なマルチセンターサンプルで,染色体1qで主要な統合失調症の場所が検出されなかった
Douglas F Levinson1, Peter A Holmans, Claudine Laurent
1Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA. dfl@mail.med.upenn.edu
まとめ
この研究では,家族の大規模なサンプルで統合失調症と染色体1qの間の有意な遺伝的関連性が見つかりませんでした. これらの発見は,もし統合失調症の感受性遺伝子が染色体1qに存在するならば,その影響はおそらく最小限であると示唆しています.
科学分野:
- 遺伝学 遺伝学とは
- 精神科医は精神病を患っている.
- 分子生物学は分子生物学である.
背景:
- 以前の報告では,統合失調症と染色体1q.の間の遺伝的関連が示唆されていた.
- 統合失調症の遺伝因子を特定することは,その病因を理解するために極めて重要です.
研究 の 目的:
- 報告されている統合失調症と染色体1qとの遺伝的関連性を厳密に評価する.
- 異なるファミリーサンプルにおける結合信号の潜在的な異質性を調査する.
主な方法:
- 染色体1q.の107センチモルガンにわたる16のDNAマーカーの遺伝子型決定.
- 779の情報的な統合失調症の血統を含むマルチセンターサンプルを分析した.
- ヨーロッパ出身の家族,後退的な遺伝モデル,複数の被災者の家族を含む階層化された分析.
主要な成果:
- 統合失調症と染色体1qとの間の遺伝的関連性に関する有意な証拠は観察されなかった.
- 8つの個々のサンプルの間でアレル共有の有意な異質性は検出されなかった.
- また,サブグループ分析では,関連性に関する有意な証拠が得られませんでした.
結論:
- 統合失調症と染色体1qの関連性に関する実質的な証拠は,この大規模な研究によって支持されていません.
- 統合失調症の感受性遺伝子が染色体1qに位置している場合,その疾患への全体的な貢献は小さい可能性があります.
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