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Updated: Jun 10, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

ベータシート展開の熱力学に対するバックボーンサイクリングの効果:PIN WWドメインの安定性最適化

Songpon Deechongkit1, Jeffery W Kelly

  • 1Department of Chemistry and The Skaggs Institute of Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC 506, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|May 2, 2002
PubMed
まとめ

バックボーンサイクリングはタンパク質の安定性を高めることができますが,リンク器の最適化は不可欠です. PIN1 WW ドメインのリンクを調整することで,線形配列と比較してベータシートの安定性が向上しました.

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