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関連する概念動画

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

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関連する実験動画

Updated: Jun 21, 2026

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
08:10

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

Published on: December 14, 2015

WNTのシグナル伝達とリンパ球の発達

Marc van de Wetering1, Wim de Lau, Hans Clevers

  • 1Department of Immunology, UMC Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

Cell
|May 2, 2002
PubMed
まとめ
この要約は機械生成です。

初期の発達における細胞運命を決める決定は,保存された信号経路に依存する. WntとNotchのシグナル伝達経路は,脊椎動物の免疫系の発達,特に早期リンパパエシスの制御に不可欠です.

さらに関連する動画

Studying Wnt Signaling During Patterning of Conducting Airways
13:00

Studying Wnt Signaling During Patterning of Conducting Airways

Published on: October 16, 2016

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
11:14

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

関連する実験動画

Last Updated: Jun 21, 2026

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
08:10

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

Published on: December 14, 2015

Studying Wnt Signaling During Patterning of Conducting Airways
13:00

Studying Wnt Signaling During Patterning of Conducting Airways

Published on: October 16, 2016

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
11:14

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

科学分野:

  • 発達生物学 発達生物学とは
  • 免疫学 免疫学とは
  • 分子生物学は分子生物学である.

背景:

  • 細胞運命を決定することは,発達にとって根本的なものです.
  • 保存された信号伝導カスケードは,種間の細胞運命を決定する決定を調節する.
  • 脊椎動物の免疫系の発達には,複雑な規制機構が関与しています.

研究 の 目的:

  • 脊椎動物の免疫細胞発達における保存されたシグナル伝達経路の役割を調査する.
  • WntとNotchのシグナル伝達経路が早期リンパ球形成に関与しているかどうかを判断する.

主な方法:

  • モデル生物を用いて発達研究を行う.
  • 保存された信号伝導カスケードを分析する.
  • 脊椎動物免疫系の初期発達過程を調査する.

主要な成果:

  • 細胞の運命を左右する少数の高度に保存された信号伝導カスケードを特定しました.
  • WntとNotchのシグナリングカスケードは,脊椎動物の免疫系によって採用されていることが判明しました.
  • WntとNotch経路が早期リンパパエシスの制御に関与することを実証した.

結論:

  • WntとNotchのシグナル伝達経路は,脊椎動物における早期リンパパエーシスの主要な調節因子である.
  • 保存された発達シグナル伝達経路は,免疫システムの発達のために再利用されています.
  • これらの発見は,免疫細胞発達の分子メカニズムについての洞察を提供します.