関連する実験動画
Updated: Jul 17, 2026

09:15
Electrochemiluminescence Assays for Human Islet Autoantibodies
Published on: March 23, 2018
1型糖尿病の小児における急性合併症の予測要因
Arleta Rewers1, H Peter Chase, Todd Mackenzie
1Pediatric Emergency Medicine, Department of Pediatrics, University of Colorado, School of Medicine, The Children's Hospital, Denver, CO 80218, USA. rewers.arleta@tchden.org
JAMA
|May 22, 2002
まとめ
糖尿病性ケトアシドーシスと重度の低血糖症は,1型糖尿病の子どもにとって重大なリスクである. 保険不足や精神疾患などの変更可能な要因は,これらのリスクを高め,ターゲットを絞った介入の必要性を強調します.
科学分野:
- 小児内分泌学について
- メタボリック障害 メタボリック障害
- 糖尿病管理 糖尿病管理
背景:
- 糖尿病性ケトアシドーシスと重度の低血糖症は1型糖尿病の重大な急性合併症である.
- これらの状態は,インスリン治療の不均衡の結果であるが,追加の修正可能なリスク要因は十分に理解されていない.
研究 の 目的:
- 糖尿病の小児におけるケトアシドーシスおよび重度の低血糖症の発生率を決定する.
- 小児の集団におけるこれらの深刻な糖尿病合併症の予測要因を特定する.
主な方法:
- 1型糖尿病の1243人の子供 (幼児から19歳) を対象とした前向きなコホート研究.
- フォローアップ期間は,デンバー都市圏で3994人年 (1996年1月 - 2000年12月) であった.
- ケトアシドーシスと重度の低血糖症の発生率の分析,入院と緊急診察を含む.
主要な成果:
- ケトアシドーシスの発生率は100人当たり8人/年であり,少女の年齢とともに増加しています. 危険因子には,より高いヘモグロビンA1c (HbA1c),より高いインスリン用量,保険不足,精神疾患が含まれていました.
- 重度の低血糖症の発生率は100人当たり19人/年であり,少女の年齢とともに減少している. 危険因子には,糖尿病の長期間,保険不足,低HbA1c,精神疾患などが含まれていました.
- 繰り返し発生するイベントは,子供の20%のエピソードの80%を占めました.
結論:
- 1型糖尿病の特定の子供は,ケトアシドーシスと重度の低血糖症の持続的な高いリスクに直面しています.
- 年齢と性別に特有のパターンは,十代の少女におけるケトアシドーシスの課題と,幼い子供と男の子における低血糖症を強調しています.
- ターゲットを絞った介入は,低保険の子ども,精神疾患の子ども,極端なHbA1c値の子どもに焦点を当てなければならない.
関連する概念動画
Diabetes Mellitus: Overview and Type I Subtype
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Diabetes Mellitus: Type 2 and Gestational
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Pathophysiology of Diabetes
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Type I Diabetes I: Introduction
Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
Type I Diabetes III: Clinical Manifestations
Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
Type II Diabetes I: Introduction
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...

