女性の出生体重と妊娠糖尿病のリスクとの関連
Kim E Innes1, Tim E Byers, Julie A Marshall
1Southeastern Rural Mental Health Center, McLeod Hall, University of Virginia, 202 15th St SW, Charlottesville, VA 22903-3306, USA. kei6n@virginia.edu
JAMA
|May 22, 2002
まとめ
女性の出生体重は,妊娠糖尿病 (GDM) のリスクと関連しています. 低体重または高出生体重はGDMのリスクを高め,初期の人生の要因がこの妊娠合併症に影響することを示唆しています.
科学分野:
- 産婦人科と産婦人科を担当しています.
- エンドクリノロジー エンドクリノロジー
- 公衆衛生は公衆衛生である.
背景:
- 妊娠中糖尿病 (GDM) は,妊娠中の重大な合併症であり,2型糖尿病の予測因子である.
- 胎児の成長は成人2型糖尿病のリスクと関連しているが,GDMとの関連はあまり理解されていない.
研究 の 目的:
- 女性自身の胎児の成長と,GDMを発症するリスクとの関係を調査する.
- 胎児の成長指数とGDMリスクの逆関連性に関する仮説を検証する.
主な方法:
- ニューヨーク州からの病院退院と生命記録をリンクして利用した,人口ベースのケース・コントロール研究.
- 1994年から1998年の間に最初の妊娠からGDMと診断された440人の女性 (症例) とGDMのない22,955人の女性 (対照群) が参加しました.
- 胎児の成長の主要な指標として,妊娠年齢に調整した出生体重を分析した.
主要な成果:
- 低出生体重 (<2000g) と高出生体重 (≥4000g) の両方でリスクが高く,出生体重とGDMリスクの間でU型関係が観察されました.
- 妊娠前のBMIや母性糖尿病などの混同要因を調整した後,低出生体重に関連するGDMリスクのオッズ比率は4.23でした.
- 出生体重とGDMリスク (トレンドに対するP調整 <.001) の間には強い反逆の投与量反応関係が見られた.
結論:
- 女性自身の出生体重は,GDMを発症するリスクと有意かつ逆に関連しています.
- これらの発見は,胎児の成長などの早期の人生の要因が,GDMの発達における潜在的な重要性を強調しています.
- 初期の生活の影響が妊娠糖尿病のエチオロギーにおいて重要な役割を果たす可能性があることを示唆しています.
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