異なる宿主特異性を有する2つのXanthomonas病原体のゲノムを比較
A C R da Silva1, J A Ferro, F C Reinach
1Departamento de Bioquímica, Instituto de Química, Av. Prof. Lineu Prestes 748, São Paulo, SP, Brazil.
Nature
|May 25, 2002
まとめ
Xanthomonas axonopodis pv.のゲノムについて Citri (Xac) とXanthomonas campestris pv. が使用されています. campestris (Xcc) が配列化され,異なる植物病にもかかわらず高い類似性を明らかにしました. 株特有の遺伝子は,それらの異なる宿主特異性と病原性を説明する可能性がある.
科学分野:
- バクテリア学 バクテリア学
- ゲノミクスゲノミクスとは
- 植物病理学 植物病理学
背景:
- ジャンスのXanthomonasは,農業に影響を与える重要な細菌の植物病原体を含んでいます.
- クサントモナス (Xanthomonas) アクソノポディス (axonopodis) Pv. について Citri (Xac) はシトルス・キャンサーを誘発し,世界の経済に大きな損失をもたらします.
- クサントモナス・キャンペストリス Pv. カンペストリス (Xcc) は,クロシファーの黒い腐食を引き起こし,キサンタンガムの源である.
研究 の 目的:
- XacとXccの完全なゲノム配列を比較するために.
- 異なる宿主範囲と疾患現象型を説明できるゲノムの違いを特定する.
主な方法:
- XacとXccの全ゲノムシーケンシング.
- 共有遺伝子と株特異遺伝子を特定するための比較ゲノム分析.
- 遺伝子順序保存の分析 遺伝子順序保存の分析 遺伝子順序保存の分析
主要な成果:
- XacとXccの間で,80%以上の遺伝子が共有され,全体的に高いゲノム類似性があります.
- ほとんどの染色体において遺伝子の順序が保たれている.
- XacとXcc.の両方の株特異性遺伝子の異なるグループを特定する.
結論:
- 類似したゲノムにもかかわらず,XacとXccは異なる病原性行動を示す.
- 株特有の遺伝子は,宿主特異性と病原性における変動に責任がある可能性が高い.
- ゲノム比較は,Xanthomonasの毒性の進化についての洞察を提供します.
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