出版までの時間間隔と統計的有意性との関連
Kay Dickersin1, Carin M Olson, Drummond Rennie
1Department of Community Health, Brown University, Providence, RI 02912, USA. kay_dickersin@brown.edu
JAMA
|June 1, 2002
まとめ
ポジティブな臨床試験結果は,ネガティブな結果より早く公表されません. 試験の質と特徴は,また,制御試験の出版速度に影響を与えませんでした.
科学分野:
- 医学研究 医学研究
- クリニック・トライアル 臨床試験
- 出版バイアスは,出版バイアスです.
背景:
- 研究は,統計学的に有意な臨床試験結果のより迅速な公表に向けたバイアスを示唆しています.
- 出版バイアスとして知られるこの現象は,科学文献を歪める可能性があります.
研究 の 目的:
- コントロールされた臨床試験から得られた肯定的な結果を報告した原稿が,否定的な結果を報告した原稿よりも早く出版されるかどうかを調査する.
- 統計的有意性,方法論的品質,および出版時間との関連性を調べる.
主な方法:
- 1996年2月から1999年8月までJAMAに提出されたトラッキングされた原稿.
- 結果をポジティブ (統計的に有意なプライマリアウトカム) またはネガティブとして分類します.
- 統計的な比較を伴う見通し試験を含む. 出版のために受け入れられた.
主要な成果:
- 含まれた133本の原稿のうち,78%が肯定的な結果を報告し,38%が否定的な結果を報告した.
- 提出から公表までの平均時間は,陽性 (7.8ヶ月) と陰性 (7.6ヶ月) の結果 (P=.44) に似ていた.
- 出版時間は,方法論的質や研究特性と関連していなかった.
結論:
- 比較試験の公表までの時間は,結果の統計的有意性に影響されませんでした.
- 方法論的質やその他の研究特性は,出版速度に影響を与えなかった.
- 調査結果は,統計的有意性に関連する出版バイアスが,この特定のジャーナルの制御試験の出版物においてそれほど一般的ではないことを示唆しています.
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