関連する実験動画
Updated: Jul 23, 2026
16:24
Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
Published on: February 21, 2014
人間のエストロゲン受容体の結合と調節
Donald P McDonnell1, John D Norris
1Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813, Durham, NC 27710, USA. donald.mcdonnell@duke.edu
Science (New York, N.Y.)
|June 1, 2002
まとめ
エストロゲン エストロゲン
科学分野:
- 内分泌学と分子生物学について
背景:
- エストロゲンは,複数の組織にわたる多様な細胞機能に影響を与えます.
- エストロゲンに対する細胞の反応は著しく変化し,その分子機構のより深い理解を必要とします.
研究 の 目的:
- エストロゲンに対する異なる細胞反応の分子基礎を解明する.
- エストロゲンシグナル伝達の特異性を支配する重要な要因を強調する.
主な方法:
- エストロゲン受容体 (ER) 作用に関する最近の分子研究のレビュー.
- ERサブタイプ,コファクター相互作用,および細胞発現パターンの分析.
主要な成果:
- 2つの異なったエストロゲン受容体 (ERs) を特定し,独特のインビボ発現プロファイルを有しました.
- ERの転写活動が特定の転写コファクター (コアクティベーター/コアプレッサー) との相互作用に依存することを実証した.
- コファクター発現と機能は細胞特異であり,均一ではないことを強調した.
結論:
- エストロゲン受容体の存在は必要ですが,エストロゲンに対する細胞応答には不十分です.
- 存在するコファクターと相互作用経路を含む特定の細胞環境は,エストロゲン反応の性質と規模を決定する.
関連する概念動画
01:31Internal Receptors
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
01:31Internal Receptors
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
01:31Transducer Mechanism: Nuclear Receptors
Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
01:22Target Cell Response to Hormones
Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
01:19Regulation of Hormone Secretion
Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral stimuli,...
Humoral stimuli,...
01:22Hormonal Regulation of the Menstrual Cycle
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.