前帯状皮質:報酬の期待度に関係する単一のニューロン信号
Munetaka Shidara1, Barry J Richmond
1Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology, 1-1-1 Umezono, Tsukuba, Ibaraki 305-8568, Japan. m.shidara@aist.go.jp
まとめ
猿は,報酬が近づくにつれて動機づけが増加し,前帯状皮質の神経細胞は,この変化する報酬期待を反映しています. この神経活動は,強迫性障害や薬物乱用などの状態で変化することがあります.
科学分野:
- 神経科学は神経科学である.
- 行動経済学は,行動経済学である.
背景:
- 報酬スケジュールを実行するサルでは,報酬が近づくにつれてエラー率が低下しています.
- この行動の変化は,動機づけや報酬の期待を高めることを示唆しています.
研究 の 目的:
- 前帯状皮質 (ACC) の報酬期待期間の変化のニューラル関連性を調査する.
- 報酬の処理が変化した条件下でのACC活動の役割を調査する.
主な方法:
- 報酬スケジュールの実行中に猿のACCにおける単一のニューロン記録.
- 報酬の近接性シグナルと期待に対する神経応答の分析.
主要な成果:
- 記録されたACCニューロンの約3分の1は,報酬の期待とともに徐々に変化する反応を示した.
- この漸進的な神経応答は,報酬のシグナルがランダムに割り当てられたときに消えた.
- 報酬期待と関連した神経の進行の変化が観察されました.
結論:
- ACCの神経活動は,タスクの実行中に報酬の期待を動的に追跡します.
- 異常なACC神経進行は,強迫性障害と薬物乱用における報酬処理障害の基礎となる可能性があります.
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