老化における肝臓シドオキャピュラー化と動脈硬化
David G Le Couteur1, Robin Fraser, Victoria C Cogger
1Centre for Education and Research on Ageing, and Anzac Research Institute, University of Sydney, Concord RG Hospital, Sydney, NSW, Australia. dlecouteur@med.usyd.edu.au
Lancet (London, England)
|June 6, 2002
まとめ
老化により肝臓の機能が低下する.
科学分野:
- ゲロントロジーはゲロントロジーの学科です.
- 血管生物学 血管生物学
- 肝臓病理学 肝臓病理学
背景:
- 心血管疾患 (CVD) は死亡の主な原因であり,高齢化が主なリスク因子である.
- 動脈硬化症は,この年齢に関連したCVDの多くを裏付けています.
- 現在の理解では,肝臓の老化と動脈硬化病原性との間には直接的な関連性がない.
研究 の 目的:
- 年齢に関連する肝臓の構造変化と動脈硬化症を結びつける新しい仮説を提案する.
- この過程における肝臓のシヌソイド内皮のフェネストレーションの役割を明らかにする.
主な方法:
- 肝臓の老化と動脈硬化に関する既存の文献のレビューと合成.
- 確立された病原性メカニズムに基づく仮説的モデル開発.
主要な成果:
- 肝臓のシヌソイド内皮の年齢関連の擬毛細化には,内皮の加厚,基礎膜の形成,およびフェネストレーションの喪失 (デフェネストレーション) が含まれます.
- このデフェネストレーションは,肝臓のシート機能を低下させ,キロミクロン残留物のクリアランスを妨げます.
- クリアランスの低下は食後の高トリグリセリデミアにつながり,動脈硬化に寄与することが知られている.
結論:
- 年齢による肝臓フェネストレーションの喪失は,動脈硬化症の発達に直接寄与する.
- 肝臓フェネストレーションの維持または回復は,年齢に関連するCVDの新たな治療戦略を提供することができます.
- 肝臓シート透過性をターゲットにすることで,高齢者の心血管疾患のリスクを軽減することができる.
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