血管切除と前立腺がんのリスク
Brian Cox1, Mary J Sneyd, Charlotte Paul
1Hugh Adam Cancer Epidemiology Unit, Department of Preventive and Social Medicine, University of Otago Medical School, PO Box 913, Dunedin, New Zealand. brian.cox@stonebow.otago.ac.nz
JAMA
|June 19, 2002
まとめ
男性の一般的な避妊手段である血管切除は,前立腺がんのリスクを増やさない. この研究では,処置から25年以上経った後でも,精管切除と前立腺がんとの関連性は見つかりませんでした.
科学分野:
- 泌尿器科 泌尿器科とは
- 腫瘍学 腫瘍学
- エピデミオロジー エピデミオロジー
背景:
- 静脈切除は,男性避妊の広く使用されている形態です.
- 静脈切除術と前立腺がんのリスクの増加との潜在的な関連について懸念が提起されています.
研究 の 目的:
- 精管切除と前立腺がんの発症リスクとの関連を調査する.
- 精管切除が前立腺がん発生率に影響するかどうかを判断する.
主な方法:
- ニュージーランドで全国的な集団ベースの症例対照研究が行われました.
- 923人の前立腺がん患者と40歳から74歳までの1224人の対照群から,電話インタビューを通じてデータを収集した.
- 前立腺がんの相対リスク (RR) は,精管切除手術を受けた男性と,手術を受けていない男性を比較して計算された.
主要な成果:
- 静脈切除と前立腺がんのリスクとの間に統計的に有意な関連性が見つかりませんでした (RR,0.92;95%CI,0.75-1.14).
- 精管切除術から経過した時間は,リスクを変化させなかった (RR, 0.92; 95% CI, 0.68-1.23 for ≥25年).
- 社会経済的な要因,地理的地域,宗教的な所属,および家族歴を調整しても,観測された結果は変化しませんでした.
結論:
- 血管切除は前立腺がんのリスクの増加と関連していません.
- この発見は,血管切除術後25年以上経過した男性でも当てはまります.
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