血管リスクに関連してワインとビールの消費量のメタ分析
Augusto Di Castelnuovo1, Serenella Rotondo, Licia Iacoviello
1Department of Vascular Medicine and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy.
Circulation
|June 19, 2002
まとめ
軽度から中等度のワインの消費は,血管リスクと有意な逆相関を示しています. ビールの消費も,血管のリスクの低下と似たような,しかしより明確な関連性を示しました.
科学分野:
- 心臓病学 心臓病学
- エピデミオロジー エピデミオロジー
- 栄養科学とは,栄養科学である.
背景:
- 疫学研究は,アルコール摂取と心血管疾患の関連性を調査してきました.
- 以前の研究は,血管リスクに対する特定のアルコール飲料の潜在的な保護効果を示唆しています.
研究 の 目的:
- ワインやビールの消費と血管疾患のリスクとの関係を評価するメタ分析を実施する.
- 異なるレベルの飲料摂取量に関連した血管のリスクを定量的に推定する.
主な方法:
- 26の研究のメタ解析は,一般的な差異ベースの方法を使用して行われました.
- ワインとビールの消費に対する血管リスクの定量的な見積もりを提供する研究からのプールのデータを分析した.
- 線量反応関係を評価するために,統計モデルが適用されました.
主要な成果:
- ワインの摂取は,非飲酒者と比較して0.68の血管疾患の相対リスクを示した (13の研究,209,418人の参加者).
- ワインの消費量についてはJ型関係が観察され,1日150mLまでの有意な逆相関が示されました.
- 適度なビールの消費は,0.78の全体的な相対リスク (15の研究,208,036人の参加者) であったが,有意な用量反応関係は見つかりませんでした.
結論:
- 軽度から中程度のワインの消費は,血管疾患のリスクの低下と有意に関連しています.
- 同じような,しかしより顕著ではない関連性は,ビール消費量で観察されました.
- ビールの場合,明確な投与量反応関係がないため,その解釈は困難である.
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