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Updated: Jul 10, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
11:01

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase

Published on: November 23, 2016

Fapy.dGはKlenow exo(-) に,デオキシアデノシンを誤って組み込むよう指示する

Carissa J Wiederholt1, Marc M Greenberg

  • 1Department of Chemistry, Colorado State University, Ft. Collins, Colorado 80523, USA.

Journal of the American Chemical Society
|June 20, 2002
PubMed
まとめ

N-(2-デオキシ-アルファ,β-d-エリトロピントフラーノシル) -N-(2,6-ダイアミノ-4-ヒドロキシ-5-フォームミドピリミジン) (Fapy.dG) は,Klenow exo-.によるDNA複製エラーを大幅に増加させます. この病変は,頻繁に誤った組み込みと非効率的な拡張を引き起こし,誤差率を8000万倍に導きます.

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