アンジオテンシン変換酵素2は,心臓機能の重要なレギュレータです
Michael A Crackower1, Renu Sarao, Gavin Y Oudit
1Amgen Research Institute/Ontario Cancer Institute and Department of Medical Biophysics and Immunology, University of Toronto, University Avenue, Toronto, Ontario M5G 2M9, Canada.
Nature
|June 21, 2002
まとめ
アンジオテンシン変換酵素2 (ACE2) は,心臓の機能に不可欠です. ACE2の発現の減少は高血圧に関連しており,その障害は重度の心不全を引き起こし,心血管の健康におけるその役割を強調しています.
科学分野:
- 心血管生物学 心血管生物学
- 遺伝学 遺伝学とは
- 高血圧の研究研究
背景:
- 心血管疾患は死亡の主な原因である.
- 高血圧は,心血管疾患の主要な危険因子です.
- 心血管の健康におけるアニオテンシン変換酵素2 (ACE2) の役割については,さらなる解明が必要である.
研究 の 目的:
- 高血圧と心臓機能におけるアニオテンシン変換酵素2 (ACE2) の役割を調査する.
- 高血圧や心血管疾患に関連する遺伝因子を特定する.
主な方法:
- 高血圧のラットモデルにおけるX染色体上の定量的な特徴の場所 (QTL) にACE2遺伝子のマッピング.
- 高血圧ラットにおけるACE2メッセンジャーRNAとタンパク質発現の分析.
- ネズミにおけるACE2の遺伝子破壊の研究と,ドロソフィラの同型ACERの研究.
- ACE2変異マウスのACE遺伝子アブレーションを含む遺伝子救済実験.
主要な成果:
- ACE2は高血圧ラットのX染色体のQTLにマップされます.
- ACE2発現は高血圧ラット株で減少しています.
- マウスにおけるACE2の障害は,心臓の機能不全,アンジオテンシンIIの上昇,心臓の低酸素遺伝子の上昇を誘発する.
- ACE2の遺伝的消去は,ACE2変異マウスの心臓のフェノタイプを救出する.
- ドロソフィラのACERの破壊は,心臓の形質変異の欠陥を引き起こす.
結論:
- ACE2は高血圧関連QTLsの候補遺伝子である.
- ACE2は,心臓機能の重要なレギュラーである.
- ACE2によって調節されるレニン-アニオテンシン系は,心臓の健康を維持する上で重要な役割を果たします.
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