TRPV3は温度に敏感なバニロイド受容体のようなタンパク質です
G D Smith1, M J Gunthorpe, R E Kelsell
1Neurology-CEDD, GlaxoSmithKline, Third Avenue, Harlow CM19 5AW, UK.
Nature
|June 22, 2002
まとめ
研究者らは,ヴァニロイド受容体のようなタンパク質3 (VRL3/TRPV3) を発見し,VR1/TRPV1.1と異なる熱感イオンチャネルを発見した. VRL3はVR1とチャネルを形成し,熱感に寄与する可能性があります.
科学分野:
- 神経科学は神経科学である.
- 分子生物学は分子生物学である.
- 感覚生理学 感覚生理学とは
背景:
- バニロイド受容体-1 (VR1/TRPV1) は,熱,酸,カプサイシンによって活性化される熱感性カチオンチャンネルです.
- VR1遺伝子の障害はカプサイシン反応に影響するが,熱的ノシセプションにはほとんど影響しないので,他の熱センサーが存在することを示唆している.
研究 の 目的:
- VR1.1と異なる新種の熱感受容体を特定する.
- 新しく特定されたバニロイド受容体ファミリーのメンバーの機能と特性を特徴付けるため.
主な方法:
- VRL3 (TRPV3) の遺伝子識別と特徴付け.
- 背根のギャングリアニューロンにおけるVRL3発現の分析.
- ヘテロログの発現とVR1.1との関連を含むVRL3の機能研究.
主要な成果:
- 識別されたバニロイド受容体のようなタンパク質3 (VRL3/TRPV3) は,熱に敏感だがカプサイシンに敏感でないイオンチャネルである.
- VRL3は約39°Cの熱活性化値を有し,感覚神経細胞でVR1と共発現する.
- VRL3はVR1と結合し,その機能を潜在的に調節する可能性があります.
結論:
- VRL3は,熱感に関与する新しい熱感性イオンチャンネルです.
- VRL3は,VR1.1と共に,異体バニロイド受容体チャネルにおける追加のサブユニットとして機能する可能性があります.
- VRL3の発見は,VR1.1を超えて熱感受機構の理解を広げています.
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