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Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors
Published on: July 16, 2012
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C型肝炎とHIV疾患の進行について
Mark S Sulkowski1, Richard D Moore, Shruti H Mehta
1Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, 1830 E Monument St, Room 448, Baltimore, MD 21287-0003, USA. msulkows@jhmi.edu
JAMA
|July 4, 2002
まとめ
C型肝炎ウイルス (HCV) 感染は,ヒト免疫不全ウイルス (HIV) 疾患の進行や抗レトロウイルス治療への反応に有意な影響を与えない. この研究では,共同感染者と非共同感染者の間で,エイズを定義する疾患,死亡リスク,または免疫回復における実質的な違いが見つかりませんでした.
科学分野:
- 感染症 感染症は感染症です.
- 免疫学 免疫学とは
- 公衆衛生は公衆衛生である.
背景:
- C型肝炎ウイルス (HCV) がヒト免疫不全ウイルス (HIV) 疾患の進行に及ぼす影響について,相反する報告がある.
- 同感染効果を理解することは,HIV患者の管理に不可欠です.
研究 の 目的:
- HCV感染がHIV疾患の臨床的および免疫的進行にどのように影響するか評価する.
- 高活性抗レトロウイルス療法 (HAART) に対する免疫応答に対するHCVの影響を評価する.
主な方法:
- 1995年から2001年にかけての都市部の米国HIV診療所の1955人の患者を対象とした前向きなコホート研究.
- フォローアップでは,AIDSを定義する疾患への進行,生存,およびCD4細胞数の変化を評価した.
- 分析は,HCV共感染状態とHAARTの有効性に関連したアウトカムを考慮した.
主要な成果:
- HCVに感染した患者と,HCVに感染していない患者の間で,エイズを定義する疾患または死亡のリスクを有意に区別することは観察されなかった.
- 低CD4カウントのサブグループは,初期死亡リスクが高く見られたが,HAARTに調整した後にHCVと独立して関連付けられることはなかった.
- 効果的なHAARTを投与された患者は,HCV共感染状態に関係なく,CD4細胞数の増加に違いはなかった.
結論:
- HCV共感染は,この都市部の米国のコホートにおける死亡率,エイズ発症,またはHAARTに対する免疫反応のリスクを実質的に変更しませんでした.
- 結果は,効果的なHAARTが,HIV疾患の進行に対するHCV共感染の潜在的な悪影響を軽減できることを示唆しています.
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