糖尿病における網膜内部の低酸素に対する暗闇の影響
1Department of Optometry and Vision Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cathays Park, Cardiff CF10 3NB, UK. neville@drasdo.co.uk
Lancet (London, England)
|July 10, 2002
まとめ
夜間照明は,糖尿病性網膜症患者のために有益である可能性があります. 酸素は,暗闇への適応後の糖尿病患者の網膜機能を改善し,夜間低酸素症の減少が視力を維持するのに役立つことを示唆しています.
科学分野:
- オフタルモロジック (眼科)
- 糖尿病学 糖尿病学
- 網膜生理学 網膜生理学とは
背景:
- 糖尿病性網膜症 (DR) は,夜間低酸素症によって開始されることがあります.
- 振動ポテンシャル (OPs) で測定される網膜内部の機能は,糖尿病患者では低下しています.
- 暗闇への適応は,糖尿病におけるOP減少を悪化させる.
研究 の 目的:
- 2型糖尿病患者の暗闇適応後のOP幅度に対する酸素吸入の影響を調査する.
- 糖尿病性網膜症の病原性における夜間低酸素の役割を調査する.
- 糖尿病性眼疾患における夜間照明の潜在的治療効果を評価する.
主な方法:
- 2型糖尿病の患者7人と健康な対照群8人が,暗闇への適応を施されました.
- 振動ポテンシャル (OP) の振幅は,酸素吸入前と吸入中に測定されました.
- 異なる酸素条件下での糖尿病患者と対照群のOP振幅の比較.
主要な成果:
- ダークアダプテーションにより,糖尿病患者のOP幅度が低下しました.
- 酸素を吸入すると,糖尿病患者のOP幅度が,酸素なしの対照群と比較できるレベルまで増加した.
- 酸素の吸入は,対照群のOP振幅に有意な影響を及ぼさなかった.
結論:
- 夜間低酸素症は,糖尿病性網膜症において網膜機能の低下に寄与する可能性があります.
- 酸素補給は,暗闇に適応した後の糖尿病患者の内網膜機能を改善します.
- 夜間照明で眠ることは,糖尿病性網膜症の管理に有益な戦略である可能性があります.
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