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Updated: May 12, 2026

Establishment of Proliferative Tetraploid Cells from Nontransformed Human Fibroblasts
10:04

Establishment of Proliferative Tetraploid Cells from Nontransformed Human Fibroblasts

Published on: January 8, 2017

p53欠乏細胞の修復されていないDNA破裂は,転位後に発がん性遺伝子増幅につながります

Chengming Zhu1, Kevin D Mills, David O Ferguson

  • 1Howard Hughes Medical Institute, The Children's Hospital and The Center for Blood Research, Boston MA 02115, USA.

Cell
|July 12, 2002
PubMed
まとめ

腫瘍の進行には,合併症と呼ばれる複雑なゲノム再編成が含まれます. p53と非同類末端結合 (NHEJ) が欠けているマウスでは,新しいマイクロホモロジー修復経路を通じて,c-mycとIgHを共増幅する共犯者を発見しました.

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Yeast As a Chassis for Developing Functional Assays to Study Human P5314:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence04:56

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

Published on: December 30, 2025

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